TargetMol

Platycodin D

Product Code:
 
TAR-T3889
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3889-5mg5mg£112.00
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TAR-T3889-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T3889-10mg10mg£142.00
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TAR-T3889-25mg25mg£195.00
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TAR-T3889-50mg50mg£262.00
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TAR-T3889-100mg100mg£389.00
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TAR-T3889-500mg500mg£788.00
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  • Further Information
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Further Information

Bioactivity:
Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.
CAS:
58479-68-8
Formula:
C57H92O28
Molecular Weight:
1225.335
Pathway:
GPCR/G Protein; Immunology/Inflammation; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Purity:
0.9943
SMILES:
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)CO[C@H]2OC(=O)[C@]23CCC(C)(C)C[C@H]2C2=CCC4[C@@]5(C)C[C@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(CO)(CO)[C@@H]5CC[C@@]4(C)[C@@]2(C)C[C@H]3O)[C@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@@H](O)[C@H](O[C@@H]2OC[C@](O)(CO)[C@H]2O)[C@H]1O
Target:
Prostaglandin Receptor; AMPK

References

Chen T, et al. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. Int Immunopharmacol. 2015 Jun;26(2):338-48. Kwon OG,ET AL. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis. Evid Based Complement Alternat Med. 2014;22014:954508. Lee S J, Kim H W, Lee S, et al. Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS. Molecules. 2022, 27(1): 107.