TargetMol

25-Hydroxycholesterol

Product Code:
 
TAR-T4717
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4717-5mg5mg£107.00
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TAR-T4717-10mg10mg£119.00
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TAR-T4717-25mg25mg£145.00
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TAR-T4717-50mg50mg£185.00
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Quantity:
TAR-T4717-100mg100mg£250.00
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Further Information

Bioactivity:
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50?65 nM) and selective suppressor of IgA production by B cells.
CAS:
2140-46-7
Formula:
C27H46O2
Molecular Weight:
402.663
Pathway:
Metabolism;
Purity:
0.9978
SMILES:
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Target:
Endogenous Metabolite; HMG-CoA Reductase

References

McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2. Lan Q, Wang C, Zhou J, et al. 25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses. International Journal of Molecular Sciences. 2021, 22(21): 11869. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.