TargetMol

Jatrorrhizine chloride

Product Code:
 
TAR-T4912
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4912-5mg5mg£102.00
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TAR-T4912-1mL1 mL * 10 mM (in DMSO)£105.00
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TAR-T4912-10mg10mg£122.00
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TAR-T4912-25mg25mg£163.00
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TAR-T4912-50mg50mg£213.00
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TAR-T4912-100mg100mg£286.00
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TAR-T4912-500mg500mg£515.00
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Further Information

Bioactivity:
Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
CAS:
6681-15-8
Formula:
C20H20ClNO4
Molecular Weight:
373.8
Pathway:
Microbiology/Virology; Neuroscience; GPCR/G Protein; Membrane transporter/Ion channel;
Purity:
0.98
SMILES:
COc(ccc1cc(-c(cc2OC)c(CC3)cc2O)[n+]3cc11)c1OC.[Cl-]
Target:
5-HT Receptor; OCT; Antibacterial; AChE

References

Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.