TargetMol

Telocinobufagin

Product Code:
 
TAR-T4A2462
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4A2462-25mg25mgEnquire
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TAR-T4A2462-1mL1 mL * 10 mM (in DMSO)£195.00
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TAR-T4A2462-10mg10mg£249.00
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Further Information

Bioactivity:
1. Telocinobufagin is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice challenged with live S. typhimurium. 3. Telocinobufagin has immunomodulatory activity, can enhance a Th1 immune response to control intracellular infections, could be developed as a novel immunotherapeutic agent to treat cancer and other immune-mediated diseases.
CAS:
472-26-4
Formula:
C24H34O5
Molecular Weight:
402.531
Purity:
0.9974
SMILES:
C[C@]12CC[C@H]3[C@@H](CC[C@]4(O)C[C@@H](O)CC[C@]34C)[C@@]1(O)CC[C@@H]2c1ccc(=O)oc1

References

Ma X, Xu W, Jin X, et al.Telocinobufagin inhibits osteosarcoma growth and metastasis by inhibiting the JAK2/STAT3 signaling pathway.European Journal of Pharmacology.2023: 175529. Wu S C , Fu B D , Shen H Q , et al. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection[J]. International Immunopharmacology, 2015, 25(2):353-362.