TargetMol

Tanshinone IIB

Product Code:
 
TAR-TN2257
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN2257-5mg5mg£1,756.00
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Quantity:
TAR-TN2257-1mL1 mL * 10 mM (in DMSO)£2,122.00
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Further Information

Bioactivity:
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development.
CAS:
17397-93-2
Formula:
C19H18O4
Molecular Weight:
310.349
Pathway:
Membrane transporter/Ion channel; Apoptosis; Proteases/Proteasome; Neuroscience
Purity:
0.98
SMILES:
Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21
Target:
BCL; Caspase; P-gp

References

Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.Drug Metab Lett. 2007 Aug;1(3):205-17.