TargetMol

Caffeic Acid Phenethyl Ester

Product Code:
 
TAR-T6429
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T6429-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T6429-25mg25mg£111.00
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TAR-T6429-50mg50mg£119.00
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TAR-T6429-100mg100mg£130.00
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Further Information

Bioactivity:
Caffeic Acid Phenethyl Ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).
CAS:
104594-70-9
Formula:
C17H16O4
Molecular Weight:
284.311
Pathway:
Apoptosis; NF-κb
Purity:
0.9993
SMILES:
Oc1ccc(C=CC(=O)OCCc2ccccc2)cc1O
Target:
Apoptosis; NF-κB

References

Li W, Yang C, Shi Z, et al.Caffeic Acid Phenethyl Ester Inhibits Ubiquitination and Degradation of p53 and Blocks Cervical Cancer Cell Growth.Current Molecular Medicine.2023 Amodio R, et al. Int J Dev Neurosci. 2003, 21(7), 379-389. Banskota AH, et al. J Ethnopharmacol. 2002, 80(1), 67-73. Yu G, Jiao Y, Huang J J, et al. Acidic preconditioning reduces lipopolysaccharide?induced acute lung injury by upregulating the expression of angiotensin?converting enzyme 2[J]. Experimental and Therapeutic Medicine. 2021, 21(5): 1-8. Chung TW, et al. J Mol Med (Berl). 2013, 91(2), 271-282. Lin HP, et al. Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. Oncotarget. 2015 Mar 30;6(9):6684-707. Zhao WX, et al. Int J Mol Med. 2014, 33(3), 687-694. Natarajan K, et al. Proc Natl Acad Sci U S A. 1996, 93(17), 9090-9095. Os?s S M, Marcos P, Azofra P, et al. Phenolic Profile, Antioxidant Capacities and Enzymatic Inhibitory Activities of Propolis from Different Geographical Areas: Needs for Analytical Harmonization[J]. Antioxidants. 2020, 9(1): 75. Zhou D, Yang S, Yan H, et al. SC75741, a novel c-Abl inhibitor, promotes the clearance of TDP25 aggregates via ATG5-dependent autophagy pathway. Frontiers in Pharmacology. 2021: 2891. Yu G, Jiao Y, Huang J J, et al. Acidic preconditioning reduces lipopolysaccharide?induced acute lung injury by upregulating the expression of angiotensin?converting enzyme 2. Experimental and Therapeutic Medicine. 2021 May;21(5):441. doi: 10.3892/etm.2021.9879. Epub 2021 Feb 28. Os?s S M, Marcos P, Azofra P, et al. Phenolic Profile, Antioxidant Capacities and Enzymatic Inhibitory Activities of Propolis from Different Geographical Areas: Needs for Analytical Harmonization. Antioxidants. 2020, 9(1): 75