TargetMol

Irinotecan Hydrochloride

Product Code:
 
TAR-T0486L
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0486L-50mg50mg£123.00
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TAR-T0486L-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T0486L-100mg100mg£149.00
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TAR-T0486L-200mg200mg£185.00
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TAR-T0486L-500mg500mg£297.00
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Further Information

Bioactivity:
Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
CAS:
100286-90-6
Formula:
C33H39ClN4O6
Molecular Weight:
623.14
Pathway:
DNA Damage/DNA Repair; Autophagy
Purity:
0.9994
SMILES:
Cl.CCc1c2cc(OC(=O)N3CCC(CC3)N3CCCCC3)ccc2nc2c1Cn1c2cc2c(COC(=O)[C@]2(O)CC)c1=O
Target:
Topoisomerase; Autophagy

References

1. Hofmann C, et al. Pre-clinical evaluation of the activity of irinotecan as a basis for regional chemotherapy. Anticancer Res. 2005 Mar-Apr;25(2A):795-804. 2. Ohdo S, et al. Cell cycle-dependent chronotoxicity of irinotecan hydrochloride in mice. J Pharmacol Exp Ther. 1997 Dec;283(3):1383-8.