TargetMol

3-O-Methylgallic acid

Product Code:
 
TAR-TN1237
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1237-100mg100mg£95.00
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TAR-TN1237-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-TN1237-500mg500mg£122.00
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Further Information

Bioactivity:
3,4-Dihydroxy-5-methoxybenzoic acid reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation in the gut. 3,4-Dihydroxy-5-methoxybenzoic acid inhibits transcription factors NF-κB, AP-1, STAT-1, and OCT-1 which are known to be activated in colorectal cancer.
CAS:
3934-84-7
Formula:
C8H8O5
Molecular Weight:
184.147
Pathway:
Apoptosis; Cell Cycle/Checkpoint; JAK/STAT signaling; NF-κb; DNA Damage/DNA Repair; Stem Cells; Membrane transporter/Ion channel
Purity:
0.9853
SMILES:
COc1cc(cc(O)c1O)C(O)=O
Target:
Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT

References

Gargouri OD, Gargouri B, Trabelsi SK, Bouaziz M, Abdelh?di R. Synthesis of 3-O-methylgallic acid a powerful antioxidant by electrochemical conversion of syringic acid. Biochim Biophys Acta. 2013 Jun;1830(6):3643-9. Forester SC, et al. Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells. J Agric Food Chem. 2010 May 12;58(9):5320-7. Forester SC, The anthocyanin metabolites gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde decrease human colon cancer cell viability by regulating pro-oncogenic signals. Mol Carcinog. 2014 Jun;53(6):432-9.