RevMab Biosciences

anti-Phospho-Myl2 (Myosin Light Chain 2v) (Ser19) Rabbit Monoclonal (RM484)

Product Code:
 
REV-31-1376-00
Product Group:
 
Primary Antibodies
Supplier:
 
RevMab Biosciences
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Recombinant Antibody
Antibody Clone:
 
RM484
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
BLUE ICE
Storage:
 
-20°C
1 / 1
Western Blot of mouse heart tissue lysate, using Anti-Phospho-Myl2 (Ser19) rabbit monoclonal antibody (clone RM484) at a 1:1000 dilution. The phospho-specificity of RM484 was verified by peptide blocking using a control non-phosphopeptide or phosphopeptide targeting residue Ser19.
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Western Blot of mouse heart tissue lysate, using Anti-Phospho-Myl2 (Ser19) rabbit monoclonal antibody (clone RM484) at a 1:1000 dilution. The phospho-specificity of RM484 was verified by peptide blocking using a control non-phosphopeptide or phosphopeptide targeting residue Ser19.

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REV-31-1376-00-R100100 ul£455.00
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This product comes from: Switzerland.
Typical lead time: 14-21 working days.
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Further Information

Alternate Names/Synonyms:
Myosin Regulatory Light Chain 2; Ventricular/cardiac Muscle Isoform, MLC-2v
Concentration:
N/A
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
A phospho-peptide corresponding to human Phospho-Myl2 (Ser19).
Long Description:
Recombinant Antibody. This antibody reacts to Myl2 (Myosin Light Chain 2v) only when phosphorylated at Ser19. There is no crossreactivity to Myl2 that is not phosphorylated. This antibody reacts to human, mouse or rat Phospho-Myl2 (Ser19). Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A phospho-peptide corresponding to human Phospho-Myl2 (Ser19). Applications: WB. Myosin is composed of six polypeptide chains: two identical heavy chains and two pairs of light chains. Myosin light chain 2 (MLC2), also known as myosin regulatory light chain (MRLC or RLC, LC20), has many isoforms depending on its distribution. In smooth muscle, MLC2 is phosphorylated at Thr18 and Ser19 by myosin light chain kinase (MLCK) in a Ca2+/calmodulin-dependent manner. The phosphorylation is correlated with myosin ATPase activity and smooth muscle contraction. ROCK also phosphorylates Ser19 of smooth muscle MLC2, which regulates the assembly of stress fiber.
NCBI, Uniprot Number:
P10916
Package Type:
Vial
Product Description:
Myosin is composed of six polypeptide chains: two identical heavy chains and two pairs of light chains. Myosin light chain 2 (MLC2), also known as myosin regulatory light chain (MRLC or RLC, LC20), has many isoforms depending on its distribution. In smooth muscle, MLC2 is phosphorylated at Thr18 and Ser19 by myosin light chain kinase (MLCK) in a Ca2+/calmodulin-dependent manner. The phosphorylation is correlated with myosin ATPase activity and smooth muscle contraction. ROCK also phosphorylates Ser19 of smooth muscle MLC2, which regulates the assembly of stress fiber.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to Myl2 (Myosin Light Chain 2v) only when phosphorylated at Ser19. There is no crossreactivity to Myl2 that is not phosphorylated. This antibody reacts to human, mouse or rat Phospho-Myl2 (Ser19).
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.