Further Information
Alternate Names/Synonyms:
A Proliferation Inducing Ligand; Tumor Necrosis Factor Ligand Superfamily Member 13; TNFSF13; TALL-2; CD256
1mg/ml
32160000
liquid
Liquid. In PBS containing 0.02% Proclin 300.
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Recombinant mouse APRIL.
Monoclonal Antibody. Recognizes mouse and human recombinant and endogenous APRIL. Isotype: Mouse IgG2b. Immunogen: Recombinant mouse APRIL. Applications: ELISA, IP. Liquid. In PBS containing 0.02% Proclin 300. APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.
Q9D777
Plastic Vial
APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.
Antibody, Immunology, Inflammation, TNF Superfamily
>95% (SDS-PAGE)
Purified from concentrated hybridoma tissue culture supernatant.
Recognizes mouse and human recombinant and endogenous APRIL.
Non-hazardous
Primary Antibodies
12352203
Stable for at least 1 year after receipt when stored at -20°C.