Leinco Technologies

Recombinant Human IL-20

Product Code:
 
LEI-I-338
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-I-338-25ug25 ug£580.00
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Further Information

Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Interleukin-20 (IL-20) is a pleiotropic inflammatory protein belonging to the IL-10 family of cytokines. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is capable of stimulating colony formation by CD34+ multipotential progenitors but not by other progenitor cells. 1 It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. A specific receptor for this cytokine is expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.2 Human IL-20 is active on mouse cells.
NCBI Gene:
50604
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
IL-20

References

1. Kupper, TS. et al. (2006) Anti-Inflamm. & Anti-Allergy Agents Med. Chem. 5:243 2. Dam, TM. et al. (2009) Br. J. Dermatol. 160:284