Leinco Technologies

Anti-Mouse IL-1β - Purified in vivo GOLD™ Functional Grade

Product Code:
 
LEI-I-437
Product Group:
 
Primary Antibodies
Host Type:
 
Hamster
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
B122
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Neutralisation
  • Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-I-437-1.0mg1.0 mg£175.00
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LEI-I-437-5.0mg5.0 mg£380.00
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LEI-I-437-25mg25 mg£1,014.00
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LEI-I-437-50mg50 mg£1,556.00
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LEI-I-437-100mg100 mg£2,159.00
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This product comes from: US.
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Further Information

Antigen Distribution:
Monocytes, tissue macrophages, Langerhan cells, dendritic cells, T lymphocytes, B lymphocytes, natural killer (NK) cells and many other B cells, T cells, related monocytes
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
E. coli -expressed, recombinant mouse IL-1β
Long Description:
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3. The B122 antibody has been reported to neutralize the bioactivity of natural or recombinant IL-1β.
NCBI Gene:
16176
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
Interleukin-1 Beta

References

1. Goldberg, Diamond, et. al (2017); PLoS ONE 12(5): e0177142 Article Link 1. Dinarello CA et al. (1996) Blood 87: 2095 2. Yuan et al. (1993) Cell 75: 641 3. Shin Maeda et al. (2005) Science 4: 735