Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488

0.2 mg/ml

DyLight® 488

This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

E. coli -expressed mouse Type II TNFR

Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.

21938

TNFR2