Leinco Technologies

Anti-Human CD62L - Purified in vivo GOLD™ Functional Grade

Product Code:
 
LEI-C2270
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
DREG56
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Blocking
  • Flow Cytometry
  • Immunofluorescence (IF)
  • Immunohistochemistry- Frozen Section (IHC-F)
  • In Vivo Assay
  • Spatial Biology
  • Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
 

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CodeSizePrice
LEI-C2270-1.0mg1.0 mg£175.00
Quantity:
LEI-C2270-5.0mg5.0 mg£380.00
Quantity:
LEI-C2270-25mg25 mg£1,014.00
Quantity:
LEI-C2270-50mg50 mg£1,556.00
Quantity:
LEI-C2270-100mg100 mg£2,159.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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Further Information

Antigen Distribution:
CD62L is expressed on most circulating leukocytes, including neutrophils, monocytes, T, B and NK cells, and human embryo trophoblasts.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Concentrated supernatant from PMA-activated human peripheral blood leukocytes
Long Description:
CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes1. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition2,3. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer?s patches, via high endothelial venules (HEVs)1. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation4.
NCBI Gene:
6402
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
CD62L

References

1. Ivetic A, et al. (2019) Front Immunol. 10:1068 2. Varki A (1994) Proc Natl Acad Sci USA. 91(16):7390-7397 3. Rosen SD. (1999) Am J Pathol. 155(4):1013-1020 4. Genbacev OD, et al. (1003) Science. 299(5605):405-8