Leinco Technologies

Anti-Human/Mouse integrin β7 (Clone FIB21) - Biotin

Product Code:
 
LEI-F157
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
FIB21
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Flow Cytometry
Shipping:
 
2-8°C
Storage:
 
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
LEI-F157-100ug100 ug£199.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: US.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • References
  • Related Products
  • Show All

Further Information

Antigen Distribution:
Integrin β7 heterodimer α4/β7 is expressed on peripheral lymphocytes, thymocytes and bone marrow progenitors. Integrin β7 heterodimer αE/β7 is expressed on intestinal IEL, dendritic epidermal T cells, T regulatory cells, CD8+ T cells in lymph nodes and lamina propria.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Biotin
Format:
This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
TK1 cells
Long Description:
Integrins are a large family of heterodimeric transmembrane molecules that mediate adhesion, migration, cell survival, and cell differentiation. β7 can pair with CD49d to form the heterodimeric integrin receptor α4β7 or with CD103 to form αEβ7. α4β7 integrin is a lymphocyte receptor for the mucosal vascular addressin MADCAM-11. αEβ7 is an α-I domain-containing integrin that is highly expressed by a variety of leukocyte populations at mucosal sites including dendritic cells, intraepithelial T cells, mast cells, and T regulatory cells. FIB21 was generated by immunizing Wister rats with TK1 murine T cell lymphoma cells2. Spleen cells were then fused with Sp2/0-Ag14 myeloma cells to create a hybridoma line. FIB21 is known to block adhesion to MADCAM-1 and E-cadherin as well as α4β7 integrin binding to VCAM-1 and fibronectin. FIB21 maps to amino acid resides 176-250, which lie within the region of β7 that specifies MADCAM-1 binding3.
Target:
Integrin Beta 7

References

1. Berlin C, Berg EL, Briskin MJ, et al. Cell. 74(1):185-195. 1993. 2. Andrew DP, Berlin C, Honda S, et al. J Immunol. 153(9):3847-3861. 1994. 3. Tidswell M, Pachynski R, Wu SW, et al. J Immunol. 159(3):1497-1505. 1997. 4. Meerschaert J, Vrtis RF, Shikama Y, et al. J Immunol. 163(11):6217-6227. 1999. 5. Higgins JM, Cernadas M, Tan K, et al. J Biol Chem. 275(33):25652-25664. 2000.