Leinco Technologies

Anti-Respiratory Syncytial Virus (RSV)

Product Code:
 
LEI-F653
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
RSV-78952
Regulatory Status:
 
RUO
Target Species:
 
Respiratory syncytial virus (RSV)
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Neutralisation
Shipping:
 
Blue Ice
Storage:
 
This product contains no stabilizing proteins and should be stored at 2-8°C until ready to use.
 

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CodeSizePrice
LEI-F653-250ug250 ug£434.00
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This product comes from: US.
Typical lead time: 14-21 working days.
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  • Further Information
  • References
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Further Information

Concentration:
100 ug/ml
Conjugate/Tag/Label:
Purified
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate-buffered saline, pH 7.2 and contains 0.1% sodium azide.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate-buffered saline, pH 7.2 and contains 0.1% sodium azide.
Long Description:
Respiratory syncytial virus (RSV) is a common respiratory virus that infects the majority of children by two years old1, 2. While usually mild, RSV can be serious in infants and older adults and is the leading cause of bronchiolitis and pneumonia in children less than one year of age in the United States1. A related pneumovirus, human metapneumovirus (hMPV), also significantly contributes to hospitalizations resulting from lower respiratory tract infection2. Antibodies have been described that bind and neutralize both RSV and hMPV fusion (F) proteins. RSV F protein is a type I integral membrane protein that is synthesized as a 574 amino acid inactive precursor, assembled into a trimer, post-translationally modified, then cleaved to produce F1, F2, and intervening peptide pep273. Functional F protein has both pre- and post-fusion conformations. RSV F protein is highly conserved among RSV isolates from both A and B subgroups3 and is the primary target for antiviral drug development3 with several antigenic regions capable of introducing neutralizing antibodies2. RSV and hMPV F protein share ~36% sequence similarity.
Purity:
>90% monomer by analytical SEC and SDS-Page
Target:
Respiratory Syncytial Virus

References

1. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases, Link Text 2. Mousa JJ, Binshtein E, Human S, et al. PLoS Pathog. 14(2):e1006837. 2018. 3. McLellan JS, Ray WC, Peeples ME. Curr Top Microbiol Immunol. 372:83-104. 2013.