MBL

Anti-CD117 (c-Kit) (Human) pAb

Product Code:
 
MBL-566-H
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-566-H6 ml£358.00
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  • Further Information
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Further Information

Alternative Names:
ICC, IHC
Background:
c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
Conjugate:
Unlabeled
Formulation:
In 20 mM HEPES/1% BSA/0.135 M NaCl/0.1% sodium azide
Gene IDs:
Human: 3815 Mouse: 16590
Immunogen Translated:
Synthetic peptide C-terminal portion of c-kit gene product carrier protein binding (K963)
Reactivity:
This antibody reacts with c-Kit on Immunohistochemistry.
Shelf Life:
3 years
Source:
This antibody was purified from rabbit serum using the synthesized peptides (C-terminal of c-Kit gene product; K963) coupled protein A agarose column. The rabbit was immunized with carrier protein conjugated synthesized peptides (K963).
Target:
KIT, PBT, SCFR

Documents

References

1) Koch, A. C., et al., Ann. N.Y. Acad. Sci. 1073, 517-526 (2006) 2) Lyford, G. L., et al., Gut 51, 496-501 (2002) 3) Sakurai, S., et al., Am. J. Pathol. 154, 23-28 (1999) 4) Tsuura, T., et al., Virchows Archiv. 424, 135-141 (1994) 5) Hidi, K., et al., Oncogene 6, 2291-2296 (1991) 6) Yarden,Y., et al., EMBO J. 6, 3341-3351 (1987) This antibody is used in the reference number 1) - 3).