Anti-SLC16A2 (MCT8) (Human) pAb

MCT8

WB - 1:1000 (chemiluminescence detection system) FCM - 1:200 ICC - 1:200 IHC - 1:1000 (Heat treatment required for paraffin)

SLC16A2, also known as monocarboxylate transporter 8 (MCT8), is responsible for the transport of thyroid hormone 3 (T3) into the nerve cells in the developing brain. After T3 is transported into a nerve cell, it interacts with intranuc lear receptors, which activate or inhibit the expression of specific genes that are related to cell migration, dendrite formation, and synapse development. SLC16A2 is also distributed in several organs such as the liver, heart, brain, thymus, intestine, ovary, prostate, pancreas, and placenta. A mutation in the SLC16A2 gene inhibits the transport of T3 into the brain and results in the Allan-Herndon-Dudley syndrome, which is characterized by severe intellectual disability and impaired movement.

50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.

Human: 6567 Mouse: 20502

Synthetic peptide derived from human SLC16A2

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including the pancreas, cerebellum and small intestine by Immunohistochemistry. The reactivity has been confirmed by Western blotting, Im munocytochemistry, and intracellular Flow cytometry to detect the full length of human SLC16A2 transiently expressed in HEK 293T cells.

1 year

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC16A2.

SLC16A2