MBL

Anti-CD157 (BST-1) (Human) mAb-FITC

Product Code:
 
MBL-D036-4
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
RF3
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
4°C
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MBL-D036-450 Tests£301.00
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Further Information

Applications:
FCM - 10-20 &ug/mL (final concentration)
Background:
?In the bone marrow (BM) hematopoietic microenvironment, stromal cells play crucial roles. Stromal cells secrete a variety of cytokines and express cell surface molecules that regulate the growth of hematopoietic cells. BM stromal cell lines derived from patients with rheumatoid arthritis (RA) have augmented ability to support the growth of a murine pre-B cell line, DW34. BST-1 (bone marrow stromal cell antigen-1) is expressed on BM stromal cell lines and is responsible for an augmented ability to support pre-B cell line growth. BST-1 is also expressed by RA-derived synovial cell lines, a myelomonocytic cell lines, and HUVEC, suggesting that BST-1 has other functional roles than just supporting pre-B cell growth.?
Conjugate:
FITC
Formulation:
50ug IgG in 100ul volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty ofwater when disposing materials containing azide into drain.
Gene IDs:
Human: 683 Mouse: 12182
Immunogen Translated:
RASV5-5 bone-marrow stromal cell line derived from RA
Reactivity:
This antibody reacts with CD157 antigen on Flow cytometry. This antibody reacts with RASV5-5 cells, and does not react with a healthy donor-derived nonsupportive cell line, NFSV1-1
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone RF3) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3X63Ag8.653 with Balb/c mouse splenocyte immunized with RA-derived BM stromal cell line RASV5-5.
Target:
BST-1/CD157

Documents

References

1) Ortolan, E., et al ., Blood 108 , 4214-4222 (2006) 2) Funaro, A., et al., Blood 104 , 4269-4278 (2004) 3) Shimaoka, Y., et al ., J. Clin. Invest. 102 , 606-618 (1998) 4) Kaisho, T., et al ., PNAS 91 , 5325-5329 (1994) 5) Itoh, M., et al ., BBRC 203 , 1309-1317 (1994) 6) Hirata, Y., et al ., FEBS Lett. 356 , 244-248 (1994) Clone RF3 is used in reference number 1) - 4).