MBL

Anti-Bcl-2 (Rat) mAb

Product Code:
 
MBL-D038-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
83-8B
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Flow Cytometry
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
1 / 2
2 / 2
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MBL-D038-3100 ug£296.00
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  • Further Information
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Further Information

Applications:
WB - 1 ug/mL (chemiluminescence detection system) FCM - 10 ug/mL
Background:
The Bcl-2 related genes can inhibit (Bcl-X L and Mcl-1) or induce (Bax, Bcl-Xs, Bag and Bad) apoptosis in several systems. Bad was identified as a Bcl-2 interacting protein using a yeast two-hybrid screening and ? expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-X L as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-Xs, Mcl-1 and A1). When Bad heterodimerized with Bcl-X L , it displaced Bax from Bcl-X L and promoted cell death.
Concentration:
1 mg/mL
Formulation:
100ug IgG in 100ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 596 Mouse: 12043
Immunogen Translated:
Rat recombinant protein Bcl-2beta
Reactivity:
This antibody reacts with human, mouse and rat Bcl-2 on Western blotting and Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from mouse ascites fluid using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell PAI with Balb/c mouse splenocyte immunized with recombinant rat Bcl-2β
Target:
Bcl-2

Documents

References

?Viollet, L., et al., J. Immunol. 177, 6685-6694 (2006) Tanaka, T., et al., Eur. Respir. J. 20 , 359-368 (2002) Tamatani, M., et al., J. Biol. Chem. 274, 8531-8538 (1999) ?Nunez, G., et al., J. Immunol.144, 3602-3610 (1990) Tsujimoto, Y., et al., Oncogene 4, 1331-1336 (1989) Vaux, D. L., et al., Nature 335, 440-442 (1988) Tsujimoto, Y., et al., Science 228, 1440-1443 (1985)