MBL

Anti-IL-18 (Human) mAb bulk_50mg

Product Code:
 
MBL-D045-3L5V
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
159-12B
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunoprecipitation (IP)
Shipping:
 
4°C
Storage:
 
-20°C
 

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MBL-D045-3L5V50 mg£148,784.00
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This product comes from: United States.
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Further Information

Applications:
IP - 5 ug/0.5 ug recombinant Human IL-18
Background:
Interleukin 18 (IL - 18) is a n 18 kDa cytokine which identified as a c ostimulatory factor for production of interferon - γ (IFN - γ ) in response to toxic shock and shares functional similarities with IL - 12. IL - 18 is synthesized as a precursor 24 kDa molecule without a signal peptide and must be cleaved to produce an active molec ule. IL - 1 converting enzyme (ICE, Caspase - 1) cleaves pro - IL - 18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL - 18 is produced from Kupffer cells, activated macroph ages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN - γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN - γ activates macrophages, enhances NK activity and B cell maturation, proliferation and Ig secretion, induces MHC class I and II antigens, and inhibits osteoclast activation. IL - 18 acts on T helper type - 1 (Th1) T cells and in combination with IL - 12 strongly induces them to produce IFN - γ . Pleiotropic effects of IL - 18 has also been reported, such as, enhancement production of IFN - γ and GM - CSF in p eripheral blood mononuclear cells, production of Th1 cytokines, IL - 2, GM - CSF and IFN - γ in T cells, enhancement of Fas ligand expression by Th1 cells.
Concentration:
1 mg/mL
Formulation:
100ug IgG in 100ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 3606 Mouse: 16173
Immunogen Translated:
Recombinant human IL-18
Reactivity:
This antibody reacts with human IL - 18 on Immunoprecipitation .
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 159-12B) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with Balb/c mouse splenocyte immunized with recombinant human IL - 18.
Target:
IL-18

Documents

References

1) Dao, T ., et al. , Cell Immunol. 173 , 230 - 235 (1996) 2) Micallef, M ., et al . , Eur. J. Immunol. 2 6 , 1647 - 1651 (1996) 3) Ushio, S ., et al. , J. Immunol. 156 , 4274 - 4279 (1996) 4) Okamura, H ., et al . , Nature 378 , 8 8 - 91 (1995)