MBL

Anti-HB-EGF (Human) mAb

Product Code:
 
MBL-D308-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3H4
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Immunocytochemistry (ICC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-D308-3100 ul£345.00
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  • Further Information
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Further Information

Applications:
WB - 1 ug/mL IP - 0.1 ug/100 uL of cell extract from 6x105 cells FCM - 5 ug/mL ICC - 1 ug/mL
Background:
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family, which binds to and activates EGF receptor (EGFR) and ErbB4. HB-EGF has been implicated in several physiological and pathological processes. Like other EGF family members, HB-EGF is synthesized as a type I transmembrane protein (proHB-EGF). ProHB-EGF is biologically active as a juxtacrine growth factor that signals to neighboring cells in a non-diffusible manner; it also functions as the receptor for diphtheria toxin (DTR). ProHB-EGF is cleaved at its juxtamembrane domain by metalloproteinases, in a process called ectodomain shedding. Ectodomain shedding of proHB-EGF yields soluble ectodomain of HB-EGF (sHB-EGF). sHB-EGF is a potent mitogen and chemoattractant for a number of cell types expressing its cognate ErbB receptor.
Concentration:
1 mg/mL
Formulation:
PBS containing 50% Glycerol (pH 7.2). No preservative is contained.
Gene IDs:
Human: 1839
Immunogen Translated:
Human HB-EGF, extracellular domain
Shelf Life:
1 year
Source:
Purified IgG from hybridoma supernatant
Target:
HB-EGF

Documents

References

1) Hamaoka, M., et al., J. Biochem. 148, 55-69 (2010) 2) Mekada, E. and Iwamoto, R., UCSD Nature Molecule Pages doi:10.1038/mp.a002932.01