MBL

Anti-HVEM mAb

Product Code:
 
MBL-K0031-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
122
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-K0031-3100 ug£323.00
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Further Information

Applications:
FCM - 10-20 ug/mL (final concentration)
Background:
Herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor (TNFR) superfamily that has a role in herpes simplex virus entry, in T cell activation and in tumor immunity. HVEM is constitutively expressed on CD4+ and CD8+ T cells, CD19+ B cells, CD14+ monocytes, neutrophils and dendritic cells (DCs). The cytoplasmic region of HVEM binds to several members of the TNFR-associated factor (TRAF) family, namely, TRAF1, TRAF2, TRAF3 and TRF5, but not to TRAF4 or TRAF6, and that it activates transcription factors NF-κB and AP-1. The co-expression of glycoprotein D (gD) and HVEM results in the inhibition of the NF-κB activation that is induced by the HVEM overexpression.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
Gene IDs:
Human: 8764 Mouse: 230979
Immunogen Translated:
Recombinant HVEM
Reactivity:
This antibody reacts with human HVEM antigen on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 122) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell Sp2/0 with Balb/c mouse splenocyte immunized with the recombinant HVEM.
Target:
HVEM

Documents

References

1) Compaan, D. M., et al., J. Biol. Chem. 280, 39553-39561 (2005) 2) Gonzalez, L. C., et al., PNAS 102, 1116-1121 (2005) 3) Jung, H.W., et al., Exp. Mol. Med. 35, 501-508 (2003) 4) La, S., et al., Mol. Cells 14, 398-403 (2002) 5) Tamada, K., et al., J. Immunol. 164, 4105-4110 (2000) 6) Zhai, Y., et al., J. Clin. Invest. 102, 1142-1151 (1998) 7) Kwon, B.S., et al., J. Biol. Chem. 272, 14272-14276 (1997) Clone 122 is used in the reference 1) - 3).