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MBL

Anti-Atg10 (Human) mAb

Product Code:
 
MBL-M151-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
5A7
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-M151-3100 ug£346.00
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  • Further Information
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Further Information

Applications:
WB - 2 ug/mL (chemiluminescence detection system)
Background:
Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Autophagy has two ubiquitin-like conjugation systems, the Atg12 and LC3-II systems. In the Atg12 conjugation system, the Atg16L-Atg12-Atg5 forms 800 kDa complex that elongates autophagic isolation membrane. After completion of the formation of the autophagosome, the Atg12-Atg5-Atg16L complex dissociates from the membrane. In recent study, nonsynonymous SNP analysis has indicated that ATG16L1 is a Crohn's disease susceptibility gene.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 83734 Mouse: 66795
Immunogen Translated:
Human full-length Atg10 (1-220 a.a.)
Reactivity:
This antibody reacts with human Atg10 (26 kDa) on Western blotting.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 5A7) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with C3H mouse lymphocyte immunized with the full-length human Atg10 (1-220 aa).
Target:
Atg10

Documents

References

1) Nemoto, T., et al., J. Biol. Chem. 278, 39517-39526 (2003) 2) Kabeya, Y., et al., EMBO J. 19, 5720-5728 (2000) 3) Mizushima, N., et al., J. Biol. Chem. 273, 33889-33892 (1998)