MBL

Anti-DICER1 (Human) pAb

Product Code:
 
MBL-RN030PW
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rabbit
Antibody Isotype:
 
Affinity Purified Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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CodeSizePrice
MBL-RN030PW100 ul£323.00
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Further Information

Applications:
WB - 1 ug/mL for chemiluminescence detection system IP - 5 ug/500 uL of cell extract from 5 x 106 cells
Background:
Dicer1 is an endonuclease of the ribonuclease III (RNase III) family. It contains a DExH RNA helicase/ATPase domain, a Piwi/Argonaute/Zwille domain, a domain of unknown function, two RNase III domains, and a double-stranded RNA (dsRNA) binding domain. Dicer1 processes dsRNAs and pre-microRNAs into short RNA fragments of about 21?25 nucleotides in length. It is an initiating factor of the RNA interference pathway and plays a role in microRNA biogenesis and function. Dicer also mediates DNA hypermethylation and gene silencing in human colon cancer cell line.
Concentration:
1 mg/mL
Formulation:
100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 23405 Mouse: 192119
Immunogen Translated:
Internal region synthetic peptide binding KLH, human DICER1
Reactivity:
This antibody reacts with human DICER1 on Western blotting and Immunoprecipitation.
Shelf Life:
1 year
Source:
This antibody was purified from rabbit serum by affinity column chromatography. The rabbit was immunized with KLH conjugated synthetic peptide, corresponding to internal region of human DICER1.
Target:
DICER1

Documents

References

1) Ting, A. H., et al., Cancer Res. 68, 2570-2575 (2008) 2) Maclae, I. J., et al., Science 311, 195-198 (2006) 3) Zhang, H., et al., Cell 118, 57-68 (2004)