Elabscience

RAG2 Polyclonal Antibody

Product Code:
 
E-AB-65916
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines using RAG2 Polyclonal Antibody at dilution of 1:1000.
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Western blot analysis of extracts of various cell lines using RAG2 Polyclonal Antibody at dilution of 1:1000.

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CodeSizePrice
E-AB-65916-60uL60uL£210.00
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E-AB-65916-120uL120uL£291.00
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E-AB-65916-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
RAG2
Background:
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
59kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human RAG2 (NP_001230715.1).
ObservedMW:
59kDa
Purification method:
Affinity purification
Target Synonym:
RAG2;RAG-2
UNIProt ID:
P55895

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