Elabscience

PNRC2 Polyclonal Antibody

Product Code:
 
E-AB-18895
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PNRC2 Polyclonal Antibody at dilution of 1:30(?200)
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Immunohistochemistry of paraffin-embedded Human liver cancer tissue using PNRC2 Polyclonal Antibody at dilution of 1:30(?200)
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Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PNRC2 Polyclonal Antibody at dilution of 1:30(?200)
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using PNRC2 Polyclonal Antibody at dilution of 1:30(?200)

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E-AB-18895-20uL20uL£125.00
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E-AB-18895-60uL60uL£172.00
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E-AB-18895-120uL120uL£237.00
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E-AB-18895-200uL200uL£344.00
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Further Information

Abbreviation:
PNRC2
Background:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.54 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human PNRC2
Purification method:
Antigen affinity purification
Target Synonym:
0610011E17Rik;D4Bwg0593e;FLJ20312;MGC11707;MGC93828;MGC99541;OTTMUSP00000010360;OTTMUSP00000010366;pnrc2;PNRC2;Proline rich nuclear receptor coactivator 2;Proline-rich nuclear receptor coactivator 2;RP11-4M23.5;RP23-161N17.3
UNIProt ID:
Q9NPJ4

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