Elabscience

UHRF1 Polyclonal Antibody

Product Code:
 
E-AB-60684
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human colon using UHRF1 Polyclonal Antibody at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Human colon using UHRF1 Polyclonal Antibody at dilution of 1:100 (40x lens).

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E-AB-60684-60uL60uL£210.00
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E-AB-60684-120uL120uL£291.00
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E-AB-60684-200uL200uL£431.00
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Further Information

Abbreviation:
UHRF1
Background:
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human UHRF1 (NP_001041666.1).
Purification method:
Affinity purification
Target Synonym:
UHRF1;ICBP90;Np95;RNF106;TDRD22;hNP95;hUHRF1;huNp95
UNIProt ID:
Q96T88

Documents