Elabscience

SNCA Polyclonal Antibody

Product Code:
 
E-AB-36111
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human kidney cancer tissue using SNCA Polyclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human kidney cancer tissue using SNCA Polyclonal Antibody at dilution of 1:200.

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Further Information

Abbreviation:
Synuclein-α
Background:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Buffer:
PBS with 0.02% sodium azide,0.5% protective protein and 50% glycerol pH 7.4.
Calculated MW:
14kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:10000
Immunogen:
Synthesized peptide derived from the Internal region of human Synuclein-α.
ObservedMW:
15kDa
Purification method:
Affinity purification
Target Synonym:
Alpha synuclein;Alpha-synuclein;Alpha-synuclein;isoform NACP140;alphaSYN;MGC105443;MGC110988;MGC127560;MGC64356;NACP;Non A beta component of AD amyloid;Non A4 component of amyloid;Non A4 component of amyloid precursor;Non-A beta component of AD amyloid;Non-A-beta component of alzheimers disease amyloid;precursor of;Non-A4 component of amyloid precursor;Non-A4 component of amyloid;precursor of;OTTHUMP00000218549;OTTHUMP00000218551;OTTHUMP00000218552;OTTHUMP00000218553;OTTHUMP00000218554;PARK 1;PARK 4;PARK1;PARK4;Parkinson disease (autosomal dominant;Lewy body) 4;Parkinson disease familial 1;SNCA;Snca synuclein;alpha (non A4 component of amyloid precursor);SYN;Synuclein alpha;Synuclein alpha 140;Synuclein;alpha (non A4 component of amyloid precursor);SYUA
UNIProt ID:
P37840

Documents

References

  • https://link.springer.com/article/10.1007/s12640-023-00637-4
  • https://www.sciencedirect.com/science/article/pii/S0006899322001822