Elabscience

P53 Monoclonal Antibody

Product Code:
 
E-AB-22015
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Clone:1H4
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 2
Western Blot analysis of 293T cells using p53 Monoclonal Antibody at dilution of 1) 1:1000 2) 1:2000.
2 / 2
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using p53 Monoclonal Antibody at dilution of 1:200.
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Western Blot analysis of 293T cells using p53 Monoclonal Antibody at dilution of 1) 1:1000 2) 1:2000.
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using p53 Monoclonal Antibody at dilution of 1:200.

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E-AB-22015-20uL20uL£125.00
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E-AB-22015-60uL60uL£172.00
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E-AB-22015-120uL120uL£237.00
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E-AB-22015-200uL200uL£344.00
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Further Information

Abbreviation:
p53
Background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Calculated MW:
44kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:200
Immunogen:
Synthetic Peptide
ObservedMW:
53kDa
Purification method:
Protein A purification
Target Synonym:
Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;FLJ92943;LFS1;Mutant tumor protein 53;p53;p53 tumor suppressor;P53;Phosphoprotein p53;Tp53;Transformation related protein 53;TRP53;Tumor protein 53;Tumor protein p53;Tumor suppressor p53
UNIProt ID:
P04637

Documents

References

  • https://www.mdpi.com/2218-273X/10/4/577/htm