Elabscience

HMGB1 Polyclonal Antibody

Product Code:
 
E-AB-15716
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 2
Western Blot analysis of Human hepatocellular carcinoma tissue, Hela and Jurkat cell, 293T cell and Human breast infiltRative duct tissue using HMGB1 Polyclonal Antibody at dilution of 1:200
2 / 2
Immunohistochemistry of paraffin-embedded Human thyroid cancer using HMGB1 Polyclonal Antibody at dilution of 1:30
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Western Blot analysis of Human hepatocellular carcinoma tissue, Hela and Jurkat cell, 293T cell and Human breast infiltRative duct tissue using HMGB1 Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human thyroid cancer using HMGB1 Polyclonal Antibody at dilution of 1:30

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E-AB-15716-20uL20uL£125.00
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E-AB-15716-60uL60uL£172.00
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E-AB-15716-120uL120uL£237.00
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E-AB-15716-200uL200uL£344.00
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  • Further Information
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Further Information

Abbreviation:
HMGB1
Background:
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
25kDa
Concentration:
0.3 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human HMGB1
Purification method:
Affinity purification
Target Synonym:
Amphoterin;Chromosomal protein;nonhistone;HMG1;DKFZp686A04236;High mobility group 1;High mobility group box 1;High mobility group protein 1;High mobility group protein B1;high-mobility group (nonhistone chromosomal) protein 1;HMG-1;HMG1;HMG3;HMGB 1;HMGB1;HMGB1;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein
UNIProt ID:
P09429

Documents

References

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689815/