Elabscience

PTPN12 Polyclonal Antibody

Product Code:
 
E-AB-92300
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of HepG2 cells using PTPN12 Polyclonal Antibody at 1:500 dilution.
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Western blot analysis of extracts of HepG2 cells using PTPN12 Polyclonal Antibody at 1:500 dilution.

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E-AB-92300-60uL60uL£210.00
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E-AB-92300-120uL120uL£291.00
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E-AB-92300-200uL200uL£431.00
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Further Information

Abbreviation:
PTPN12
Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
88kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human PTPN12
ObservedMW:
110KDa
Purification method:
Affinity purification
Target Synonym:
PTPG1; PTP-PEST
UNIProt ID:
Q05209

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