Elabscience

SHH Polyclonal Antibody

Product Code:
 
E-AB-93248
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using SHH Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using SHH Polyclonal Antibody at 1:1000 dilution.

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E-AB-93248-60uL60uL£210.00
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E-AB-93248-120uL120uL£291.00
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E-AB-93248-200uL200uL£431.00
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Further Information

Abbreviation:
SHH
Background:
Mouse Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other twofamily members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signalingmolecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles inregulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult,including the division of adult stem cells and the development of certain cancers and other diseases.Mouse Shhis synthesized as a 437 aa precursor that contains a 24 aa signal sequence and a 413 aa mature region. Themature region is autocatalytically processed into a nonglycosylated, 20 kDa, 174 aa N-terminal fragment (Shh-N), and a catalytic-processing,glycosylated, 34 kDa, 239 aa C-terminal fragment. The 20 kDa Shh-N fragment isthe core of the active hedgehog molecule. Mouse Shh-N is 99%, 98%, and 100% aa identical to human, rat andgerbil Shh-N, respectively.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of mouse SHH
ObservedMW:
45KDa
Purification method:
Affinity purification
Target Synonym:
9530036O11Rik; Dsh; Hhg1; Hx; Hxl3; M100081
UNIProt ID:
Q62226

Documents