CD74 Antibody

ELISA (order BSA-free format for coating)

Optimal dilution of the CD74 antibody should be determined by the researcher.

CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

SU-DHL-4 lymphoma cells were used as the immunogen for the CD74 antibody.

This CD74 antibody is available for research use only.

Cell surface, Paranuclear globular

Protein A/G affinity

P044233