NSJ Bioreagents

GITR Antibody / TNFRSF18

Product Code:
 
NSJ-V3050SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2b lambda
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
DTA-1
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunofluorescence (IF)
Storage:
 
Store the GITR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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SDS-PAGE Analysis of Purified, BSA-Free GITR Antibody (clone DTA-1). Confirmation of Integrity and Purity of the Antibody.
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SDS-PAGE Analysis of Purified, BSA-Free GITR Antibody (clone DTA-1). Confirmation of Integrity and Purity of the Antibody.

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NSJ-V3050SAF-100UG100 ug£534.00
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Further Information

Application Details:
Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 0.5-1ug/ml
Application Note:
Optimal dilution of the GITR antibody should be determined by the researcher.
Description:
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.
Limitation:
This GITR antibody is available for research use only.
Localization:
Secreted, cell surface
Purity:
Protein G affinity chromatography
Uniprot #:
O35714 (Mouse)

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