NSJ Bioreagents

YY1 Antibody

Product Code:
 
NSJ-V4366SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
YY1/5436
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Aliquot the YY1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of human Daudi cell lysate with YY1 antibody (YY1/5436). Predicted molecular weight ~45 kDa but commonly observed at 45~65 kDa.~
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IHC staining of FFPE human tonsil tissue with YY1 antibody (YY1/5436). Inset: PBS used in
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Western blot testing of human Daudi cell lysate with YY1 antibody (YY1/5436). Predicted molecular weight ~45 kDa but commonly observed at 45~65 kDa.~
IHC staining of FFPE human tonsil tissue with YY1 antibody (YY1/5436). Inset: PBS used in

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NSJ-V4366SAF-100UG100 ug£534.00
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Further Information

Application Details:
Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Description:
The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal end. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3' enhancer and immunoglobulin heavy-chain �E1 site as well as the P5 promoter of the adenoassociated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
A His-tagged YY1 protein was used as the immunogen for the YY1 antibody.
Limitation:
This YY1 antibody is available for research use only.
Localization:
Nucleus
Purity:
Protein A/G affinity
Uniprot #:
P25490

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