Product Code:
TAR-T10065L
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Further Information
2',3'-cGAMP sodium, a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate immune response to pathogenic cytoplasmic DNA.
2',3'-cGAMP, as the second messenger in the cGAS-STING signaling pathway, plays a crucial role in various pathological and physiological processes, including anti-infection, anti-tumor responses, autoimmune diseases, and inflammatory conditions. Consequently, the STING signaling pathway is a promising target for drug development. Additionally, the natural synthesis yield of 2',3'-cGAMP is low, and the phosphodiester bonds in its structure are susceptible to enzymatic degradation. Therefore, structural modifications of 2',3'-cGAMP to enhance stability contribute significantly to its pharmaceutical value.
2734858-36-5
2',3'-cGAMP sodium, a cGAMP synthase (cGAS) affecting cytoplasmic DNA production as a second messenger, is a transmembrane bridging protein that is a key component of the cellular innate immune response to pathogenic cytoplasmic DNA.
C20H22N10Na2O13P2
2',3'-cGAMP can bind to STING, activating a cascade of downstream signaling events. The cGAS-STING signaling pathway serves as an intracellular surveillance system. When DNA from viruses or cancer cells enters the cytoplasm, cGAS (cyclic GMP-AMP synthase) is activated and catalyzes the synthesis of 2',3'-cGAMP from ATP and GTP. 2',3'-cGAMP acts as a warning signal, activating the STING (Stimulator of Interferon Genes) pathway. This ultimately induces the production of type I interferon (IFN-β) and other cytokines, initiating the immune response.
718.37
0.98
Anti-infective Research; Tumours; Inflammation; Immune Diseases
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