MBL

CDK6 Rabbit mAb

Product Code:
 
MBL-CNA0106S
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
ARC0224
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
ice pack : 2 to 4°C temperature range.
Storage:
 
Store at -20°C
 

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MBL-CNA0106S100 uL£442.00
Quantity:
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Further Information

Application Note:
WB,1:500 - 1:1000
Background:
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly.
Conjugate:
Unconjugated
Formulation:
PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol
Gene Accession Number:
CDK6
Gene ID:
1021
GeneID: Human:
1021
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 227-326 of human CDK6 (Q00534).
Molecular Weight:
37kDa
Peptide Sequence:
QLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
SwissProtID:
Q00534

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