MBL

Cation-independent M6PR (IGF2R) Rabbit pAb

Product Code:
 
MBL-CNA13022T
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunocytochemistry (ICC)
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
ice pack : 2 to 4°C temperature range.
Storage:
 
Store at -20°C
 

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MBL-CNA13022T100 uL£442.00
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This product comes from: United States.
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Further Information

Application Note:
WB,1:500 - 1:1000 | IF/ICC,1:50 - 1:200
Background:
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).
Conjugate:
Unconjugated
Formulation:
PBS with 0.01% thimerosal, 50% glycerol
Gene Accession Number:
IGF2R
Gene ID:
3482
GeneID: Human:
3482
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 2327-2491 of human Cation-independent M6PR (Cation-independent M6PR (IGF2R)) (NP_000867.2).
Molecular Weight:
274kDa
Peptide Sequence:
YKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI

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