HMGCR Rabbit pAb

Product Code:

MBL-CNA1633T

Product Group:

Primary Antibodies

Supplier:

MBL

Host Type:

Rabbit

Antibody Isotype:

IgG

Antibody Clonality:

Polyclonal

Regulatory Status:

RUO

Target Species:

Human
Mouse
Rat

Applications:

Immunocytochemistry (ICC)
Immunofluorescence (IF)
Immunohistochemistry- Paraffin Embedded (IHC-P)
Western Blot (WB)

Shipping:

ice pack : 2 to 4°C temperature range.

Storage:

Store at -20°C

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Code	Size	Price

MBL-CNA1633T

100 uL

£442.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Application Note:

WB,1:1000 - 1:4000 | IHC-P,1:50 - 1:100 | IF/ICC,1:50 - 1:200

Background:

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Conjugate:

Unconjugated

Formulation:

PBS with 0.01% thimerosal, 50% glycerol

Gene Accession Number:

HMGCR

Gene ID:

3156

GeneID: Human:

3156

Immunogen:

A synthetic peptide corresponding to a sequence within amino acids 700-800 of human HMGCR (NP_000850.1).

Molecular Weight:

97kDa

Peptide Sequence:

EGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSI

Documents

Datasheet