NSJ Bioreagents

Recombinant GZMB Antibody / Granzyme B

Product Code:
 
NSJ-V9489
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2a, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
rGZMB/4538
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Aliquot the recombinant GZMB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
1 / 4
Western blot testing of human spleen tissue lysate using recombinant GZMB antibody (clone rGZMB/4538). Predicted molecular weight: 29-37 kDa.
2 / 4
IHC staining of FFPE human tonsil tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
3 / 4
IHC staining of FFPE human spleen tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
4 / 4
SDS-PAGE analysis of purified, BSA-free recombinant GZMB antibody (clone rGZMB/4538) as confirmation of integrity and purity.
❮❯

Western blot testing of human spleen tissue lysate using recombinant GZMB antibody (clone rGZMB/4538). Predicted molecular weight: 29-37 kDa.
IHC staining of FFPE human tonsil tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human spleen tissue with recombinant GZMB antibody (clone rGZMB/4538). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant GZMB antibody (clone rGZMB/4538) as confirmation of integrity and purity.

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CodeSizePrice
NSJ-V9489-20UG20 ug£264.00
Quantity:
NSJ-V9489-100UG100 ug£534.00
Quantity:
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Further Information

Application Details:
Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml
Description:
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A portion of amino acids 73-187 was used as the immunogen for the recombinant GZMB antibody.
Localisation:
Cytoplasm
Purity:
Protein A/G affinity
Uniprot #:
P10144