AdipoGen Life Sciences

anti-PIDD (mouse) mAb (Lise-1)

Product Code:
 
AG-20B-0038
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Lise-1
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Shipping:
 
-20°C
Storage:
 
-20°C
1 / 1
Mouse PIDD is detected in primary MEF cells using anti-PIDD (mouse), mAb (Lise-1) (Prod. N?AG-20B-0038). Method:: Cell extracts from mouse embryo fibroblasts (MEFs) either from WT (A-B) or PIDD KO cells (C-D) were separated by SDS-PAGE under
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Mouse PIDD is detected in primary MEF cells using anti-PIDD (mouse), mAb (Lise-1) (Prod. N?AG-20B-0038). Method:: Cell extracts from mouse embryo fibroblasts (MEFs) either from WT (A-B) or PIDD KO cells (C-D) were separated by SDS-PAGE under

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Further Information

Alternate Names/Synonyms:
p53-induced Protein with a Death Domain; Leucine-rich Repeat and Death Domain-containing Protein; Lrdd
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Mouse PIDD (Death Domain).
Long Description:
Monoclonal Antibody. Recognizes mouse PIDD. Isotype: Mouse IgG2bkappa. Clone: Lise-1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
NCBI, Uniprot Number:
Q9ERV7
Package Type:
Plastic Vial
Product Description:
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes mouse PIDD.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

PIDD orchestrates translesion DNA synthesis in response to UV irradiation: E. Logette, et al.; Cell Death Diff. 18, 1036 (2011)