AdipoGen Life Sciences

anti-Podoplanin (human) mAb (18H5)

Product Code:
 
AG-20T-0100
Product Group:
 
Primary Antibodies
Antibody Clonality:
 
Monoclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
-20°C
Storage:
 
+4°C
 

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AG-20T-0100-C100100 ug£400.00
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Further Information

Alternate Names/Synonyms:
Glycoprotein 36; PA2.26 Antigen; Aggrus
EClass:
32160000
Form (Short):
solid
Formulation:
Lyophilized.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
MDCK cells stably expressing podoplanin.
Long Description:
Monoclonal Antibody. Recognizes human podoplanin. Isotype: Mouse IgG1. Clone: 18H5. Applications: FACS, IHC, WB. Lyophilized. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
NCBI, Uniprot Number:
N/A
Package Type:
Plastic Vial
Product Description:
Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
Purity:
Protein G purified.
Specificity:
Recognizes human podoplanin.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.

References

Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade: F. Spinella, et al.; Cancer Res. 69, 2669 (2009) | Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor: S. Fiorentini, et al.; J. Gen. Virol. 92, 650 (2011)