ProSci

DR6 Antibody

Product Code:
 
PSI-2157
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.
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Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.

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CodeSizePrice
PSI-2157-0.02mg0.02mg£150.00
Quantity:
PSI-2157-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
Application Note:
DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Background References:
  • Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998;431:351-6
Buffer:
DR6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (73%), Mouse: (73%)
Immunogen:
DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6.

The immunogen is located within amino acids 30 - 80 of DR6.
NCBI Gene ID #:
27242
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 21
NCBI Official Symbol:
TNFRSF21
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
AF068868
Protein GI Number:
3549262
Purification:
DR6 Antibody is Antibody is DEAE purified.
Research Area:
Apoptosis
Swissprot #:
O75509
User NOte:
Optimal dilutions for each application to be determined by the researcher.