ProSci

ARC Antibody

Product Code:
 
PSI-2185
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
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Western blot analysis of ARC in HeLa whole cell lysates with ARC antibody at 1:500 dilution.
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Western blot analysis of ARC in HeLa whole cell lysates with ARC antibody at 1:500 dilution.

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CodeSizePrice
PSI-2185-0.02mg0.02mg£150.00
Quantity:
PSI-2185-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
ARC Antibody: ARC, FCM, MYP, NOP, NOP30, ARC, Nucleolar protein 3, Apoptosis repressor with CARD, Myp
Application Note:
ARC antibody can be used for detection of ARC by Western blot at 1:500 dilution. An approximately 25 kDa band can be detected.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
ARC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
Background References:
  • Koseki T, Inohara N, Chen S, Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci USA 1998;95:5156-60
  • Stoss O, Schwaiger FW, Cooper TA, Stamm S. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. J Biol Chem 1999;274(16):10951-62
  • Geertman R, McMahon A, Sabban EL. Cloning and characterization of cDNAs for novel proteins with glutamic acid-proline dipeptide tandem repeats. Biochim Biophys Acta 1996;1306(2-3):147-52 (WD 0300)
Buffer:
ARC Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ARC antibody was raised against a 17 amino acid peptide near the amino terminus of human ARC.

The immunogen is located within the first 50 amino acids of ARC.
NCBI Gene ID #:
8996
NCBI Official Name:
nucleolar protein 3 (apoptosis repressor with CARD domain)
NCBI Official Symbol:
NOL3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
25 kDa
Protein Accession #:
NP_003937
Protein GI Number:
4505419
Purification:
ARC Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
O60936
User NOte:
Optimal dilutions for each application to be determined by the researcher.