Further Information
Bonzo Antibody: BONZO, CD186, STRL33, TYMSTR, BONZO, C-X-C chemokine receptor type 6, CDw186, CXC-R6
Bonzo antibody can be used for detection of Bonzo by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Bonzo Antibody: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor. Bonzo/STRL33 serves as coreceptor for SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.
- Deng HK, Unutmaz D, KewalRamani VN, et al. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997; 388:296-300.
- Liao F, Alkhatib G, Peden KW, et al. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 1997; 185:2015-23.
- Alkhatib G, Liao F, Berger EA, et al. A new SIV co-receptor, STRL33. Nature 1997; 388:238.
- Loetscher M, Amara A, Oberlin E, et al. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr. Biol. 1997; 7:652-60.
Bonzo Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Bonzo antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bonzo/STRL33.
The immunogen is located within the first 50 amino acids of Bonzo.
10663
chemokine (C-X-C motif) receptor 6
CXCR6
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 38 kDa
Observed: 43 kDa
AAB64221
2253422
Bonzo Antibody is affinity chromatography purified via peptide column.
Chemokines & Cytokines
O00574
Optimal dilutions for each application to be determined by the researcher.