Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
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![Western blot analysis of ILPIP in human brain lysate with ILPIP antibody at (A) 1 and (B) 2 μg/mL. Western blot analysis of ILPIP in human brain lysate with ILPIP antibody at (A) 1 and (B) 2 μg/mL.](https://www.prosci-inc.com/static-images/3199oem.jpg)
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![Immunohistochemistry of ILPIP in human brain tissue with ILPIP antibody at 10 μg/mL. Immunohistochemistry of ILPIP in human brain tissue with ILPIP antibody at 10 μg/mL.](https://www.prosci-inc.com/static-images/ILPIP-Antibody_IHC_3199.jpg)
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United States.
Typical lead time:
14-21 working days.
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Further Information
ILPIP Antibody: PAPK, ILPIP, ILPIPA, ALS2CR2, CALS-21, PRO1038, STE20-related kinase adapter protein beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, STRAD beta
ILPIP antibody can be used for the detection of ILPIP by Western blot at 1 to 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
ILPIP Antibody: ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1β converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
- Sanna MG, Correia JS, Luo Y, et al. (2002) ILPIP, a novel anti-apototic protein that enhances XIAP-mediated activation of JNK and protection of apoptosis. J. Biol. Chem. 277:30454-62.
- Sanna MG, Duckett CS, Richter BW, et al. (1998) Selective activation of JNK1 is necessary for the anti-apototic activity of hILP. Proc. Natl. Acad. Sci USA 95:6015-20.
- Nishigaki K, Thompson D, Yugawa T, et al. (2003) Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. J. Biol. Chem. 278:13520-30.
ILPIP Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
ILPIP antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ILPIP.
The immunogen is located within amino acids 280 - 330 of ILPIP.
55437
STE20-related kinase adaptor beta
STRADB
Homo sapiens
Liquid
NP_061041
13027388
ILPIP Antibody is affinity chromatography purified via peptide column.
Apoptosis
Q9C0K7
Optimal dilutions for each application to be determined by the researcher.