ProSci

RPA Interacting Protein Antibody

Product Code:
 
PSI-4013
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 2
Western blot analysis of RPA Interacting Protein in Jurkat cell lysate with RPA Interacting Protein antibody at (A) 1 and (B) 2 μg/mL.
2 / 2
Immunohistochemistry of RPA Interacting Protein in mouse stomach tissue with RPA Interacting Protein antibody at 2.5 μg/mL.
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Western blot analysis of RPA Interacting Protein in Jurkat cell lysate with RPA Interacting Protein antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of RPA Interacting Protein in mouse stomach tissue with RPA Interacting Protein antibody at 2.5 μg/mL.

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CodeSizePrice
PSI-4013-0.02mg0.02mg£150.00
Quantity:
PSI-4013-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
RPA Interacting Protein Antibody: RIP, HRIP, RIP, RPA-interacting protein, hRIP
Application Note:
RPA Interacting Protein antibody can be used for detection of RPA Interacting Protein by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
RPA Interacting Protein Antibody: Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair and recombination. RPA interacting protein (RPA IP) has been identified as an adapter protein that is involved in RPA nuclear import instead of the prototypical importin proteins that normally mediate nuclear import. Multiple isoforms of RPA IP are known to exist, with the longest isoform localized to the cytoplasm. Isoform 2 is sumoylated and is located in the PML nuclear body within the nucleus. It has been suggested that this isoform mediates the localization of the RPA complex into the PML nuclear body, thereby participating in RPA function in DNA metabolism.
Background References:
  • Zou Y, Liu Y, Wu X, et al. Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J. Cell Physiol. 2006; 208:267-73.
  • Jullien D, Gorlich D, Laemmli UK, et al. Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin α. EMBO J. 1999; 18:4348-58.
  • Park J, Seo T, Kim H, et al. Sumoylation of the novel protein hRIPbeta is involved in replication protein A deposition in PML nuclear bodies. Mol. Cell Biol. 2005; 25:8202-14. (06-01D)
Buffer:
RPA Interacting Protein Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
RPA IP antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RPA IP.

The immunogen is located within the last 50 amino acids of RPA Interacting Protein.
NCBI Gene ID #:
84268
NCBI Official Name:
RPA interacting protein
NCBI Official Symbol:
RPAIN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001028174
Protein GI Number:
74136541
Purification:
RPA Interacting Protein Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q86UA6
User NOte:
Optimal dilutions for each application to be determined by the researcher.