ProSci

TRBP1 Antibody

Product Code:
 
PSI-4011
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of TRBP1 in 3T3 cell lysate with TRBP1 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of TRBP1 in 3T3 cell lysate with TRBP1 antibody at (A) 1 and (B) 2 μg/mL.

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CodeSizePrice
PSI-4011-0.02mg0.02mg£150.00
Quantity:
PSI-4011-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
TRBP1 Antibody: TRM3, TRP185, TRP-185, TRM3, Probable methyltransferase TARBP1, TAR RNA-binding protein 1
Application Note:
TRBP1 antibody can be used for detection of TRBP1 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
TRBP1 Antibody: The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1α (EF-1α), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB). TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.
Background References:
  • Gatignol A, Buckler-White A, Berkhout B, et al. Characterization of a human TAR REN-binding protein that activates the HIV-1 LTR. Science 1991; 251:1597-1600.
  • Wu-Baer F, Lane WS, and Gaynor RB. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J. Biol. Chem.1996; 271:4201-8.
  • Wu-Baer F, Lane WS, and Gaynor RB. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 1995; 14:5995-6009.

    (07-01D)
Buffer:
TRBP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TRBP1 antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRBP1.

The immunogen is located within amino acids 1310 - 1360 of TRBP1.
NCBI Gene ID #:
6894
NCBI Official Name:
TAR (HIV-1) RNA binding protein 1
NCBI Official Symbol:
TARBP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_005637
Protein GI Number:
110825988
Purification:
TRBP1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
Swissprot #:
Q13395
User NOte:
Optimal dilutions for each application to be determined by the researcher.