Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
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Further Information
TP1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, TP1, Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1
TP1 antibody can be used for detection of TP1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
- Greider CW. Telomere length regulation. Annu. Rev. Biochem.1996; 274:92-7.
- Cong YS, Wright WE, and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev.2002; 66:407-25.
- Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science1997; 275:973-7.
- Wong JMY and Collins K. Telomere maintenance and disease. Lancet2003; 362:983-8.
TP1 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/ml
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
TP1 antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human TP1.
The immunogen is located within the first 50 amino acids of TP1.
7011
telomerase-associated protein 1
TEP1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 290 kDa
Observed: 290 kDa
AAC51107
1848277
TP1 Antibody is affinity chromatography purified via peptide column.
Homeostasis
Q99973
Optimal dilutions for each application to be determined by the researcher.